Scher AI, Stewart WF, Ricci JA, Lipton RB (November 2003).

'Acute migraine medications and evolution from episodic to chronic migraine: a longitudinal population-based study'.

Bigal ME, Serrano D, Buse D, Scher A, Stewart WF, Lipton RB (September 2008).

'Excessive opioid use and the development of chronic migraine'.

^ a b American Headache Society (September 2013), 'Five Things Physicians and Patients Should Question', Choosing Wisely: an initiative of the ABIM Foundation, American Headache Society, archived from the original on 3 December 2013, retrieved 10 December 2013, which cites.

Institute for Clinical Systems Improvement (2011), Headache, Diagnosis and Treatment of, Institute for Clinical Systems Improvement, archived from the original on, retrieved.

'EFNS guideline on the drug treatment of migraine-revised report of an EFNS task force'.

Evers S, Afra J, Frese A, Goadsby PJ, Linde M, May A, Sándor PS (September 2009).

'Practice parameter: evidence-based guidelines for migraine headache (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology'.

^ American Academy of Neurology (February 2013), 'Five Things Physicians and Patients Should Question', Choosing Wisely: an initiative of the ABIM Foundation, American Academy of Neurology, archived from the original on Septem, retrieved Aug, which cites.^ 'Butalbital and Acetaminophen - FDA prescribing information, side effects and uses'.Use of butalbital and alcohol, benzodiazepines, and other CNS-depressants can contribute to coma, and in extreme cases, fatality. Mixing with alcohol, benzodiazepines, and other CNS-depressants increases the risk of intoxication, increases respiratory depression, and increases liver toxicity when in combination with paracetamol (acetaminophen). Taking butalbital-based medications with some other drugs may also increase the side effects of the other medication.īutalbital can cause dependence or addiction. Inhibitors of the hepatic enzyme CYP3A4 may also increase the risk, severity, and duration of side effects, many drugs inhibit this enzyme as do some foods such as grapefruit and the blood orange. opioids), can cause life-threatening respiratory depression and death. In particular, butalbital, especially when combined with other sedatives (e.g. ethanol, opiates, benzodiazepines, antihistamines). The risk and severity of all side effects is greatly increased when butalbital (or butalbital-containing medications) are combined with other sedatives (ex. Rare side-effects include Stevens–Johnson syndrome, an adverse reaction to barbiturates, and anaphylaxis. Respiratory depression (impaired breathing).Commonly reported side effects for butalbital, some of which tend to subside with continued use, include: Side effects for any psychoactive drug are difficult to predict, though butalbital is usually well tolerated. When other treatments are unavailable or ineffective, butalbital may be appropriate if the patient can be monitored to prevent the development of chronic headache. Butalbital is not recommended as a first-line treatment because it impairs alertness, brings risk of dependence and addiction, and increases the risk that episodic headaches will become chronic. There are specific treatments which are appropriate for targeting migraines and headaches. Ergotamine tartrate, caffeine, butalbital, belladonna alkaloids (trade name: Cafergot-PB).

Butalbital, aspirin, caffeine, and codeine phosphate (trade name: Fiorinal#3 with Codeine).Butalbital and aspirin (trade name: Axotal).Butalbital, paracetamol (acetaminophen), caffeine, and codeine phosphate (trade name: Fioricet#3 with Codeine).Butalbital, paracetamol (acetaminophen), and caffeine (trade names: Fioricet, Esgic, Esgic-Plus, Orbivan, Fiorinal, Fiormor, Fiortal, Fortabs, Laniroif).Butalbital and acetaminophen ( paracetamol) (trade names: Axocet, Bucet, Bupap, Cephadyn, Dolgic, Phrenilin, Forte, Sedapap).

Butalbital acetaminophen caffeine